MET is over-expressed in the early stage of pancreatic carcinogenesis. Development and proliferation of several cancers appear to involve c-MET signaling. c-MET receives the hepatocyte growth factor (HGF), which initiates cell division for embryogenesis and wound healing. HGF and c-MET are currently a major focus in cancer drug advancement.
Mesenchymal-epithelial transition libro de ucdm (MET) factor is a gene that codes a protein that induces cellular growth during embryogenesis and for wound healing. The MET gene encodes for the protein c-MET receptor, which is also known as the hepatocyte growth factor receptor (HGFR). HGFR receives the hepatocyte growth factor (HGF). The connectivity between and HGF activate a tyrosine kinase signaling cascade that regulates cell growth, cell motility, and morphogenesis. HGF is the only substance that binds to c-MET.
Triggering MET elicits mitogenesis (chromosomal cell division) and morphogenesis (tissue and organ differentiation). The cellular invasive growth mechanism produce by MET is essential during embryogenesis and wound healing. As the embryo is formed and develops the MET is critical in gastrulation (formation of the early embryonic endoderm, ectoderm, and mesoderm), angiogenesis (development of new blood vessels), myoblast positioning (muscle stem cells forming different muscle types), bone transformation, and neuron emergence.
The downside to MET is it can become uncontrolled causing tumor growth and producing angiogenesis, creating new blood vessels that supply new tumor cells with nutrients. Cancer cells that have an uncharacteristic MET foundation are typically a regrettable diagnosis. Breast, liver, lung, ovary, kidney, pancreas, and thyroid carcinomas display continuous c-
MET is a receptor tyrosine kinase (RTK). Kinase enzymes specifically phosphorylate (add a phosphate group (PO4)) tyrosine amino acids. RTK’s are a type of cell surface receptors that have a strong attraction for many polypeptides (amino acid or short-chain proteins). Currently fifty-eight RTKs have been identified, and are grouped into twenty subfamilies. Cellular growth, differentiation, metabolism, adhesion, motility, and death are critical to RTK function.
When the biomolecule attaches to the extracellular region the RTK transforms inducing enzymatic activity. The kinase portion changes giving complimentary admission to adenosine triphosphate (ATP) and the substrate to the active site. Intracellular proteins are phosphorylated causing a signal to the nucleus changing gene expression. Occurrence of these processes are able to produce oncogenesis (tumor formation), by gene mutation (change in DNA sequence), chromosome translocation (combining genes from 2 separate chromosomes), or over-expression (genes producing an increased quantity of proteins).
The 2009 NY Mets are poised for a run at the 2009 World Series, this time Shea Stadium won’t be standing there to help. Shea Stadium has come down as I write and a new home for the NY Mets is fully erected. The NY Mets cannot say that Shea Stadium and luck have not collided in the past, for example the 1986 World Series victory over the Boston Redsox is a prime example. There was more than just wind blowing through the legs of Boston Redsox 1st baseman, Bill Buckner. At closer look, their was also the infield dirt that grabbed his old garbled legs and would not allow him to move, leading the NY Metropolitans to that incredible World Series victory in game 7.
In 1969, during the historic chase down of the Chicago Cubs, it was the field at Shea, that beat the opponents down to the ground and all but helped the NY Mets complete that infamous drive to the finish line in dramatic fashion destroying an insurmountable lead by those same lovable Cubs. The NY Mets went on to beat the Baltimore Orioles in the 1969 World Series and wrapped up an unbelievable season. Let us not forget, Tug McGraw “You Gotta Believe!”
The NY Mets front office has already picked up the option on NY Mets 1st baseman Carlos Delagado (RC pictured) and has all but cut ties with Pedro Martinez and Oliver Perez. Pedro “Who is your Daddy?” Martinez has been the most expensive bust in NY Mets history. 53 Million dollars and for what? Those were clearly passion filled dollars, from a passionate General Manager, with a passionate pitcher in an old man’s body that clearly could not perform. The core NY Mets are coming back, David Wright, Jose Reyes, Carlos Beltran, Carlos Delgado, the biggest questions marks were at the closer position, and the newly acquired K-Rod will certainly fill those large empty Billy Wagner shoes, with Billy Wagner on the shelf for the 2009 season. Billy Wagner is likely to retire as a result of the injury. With C.C. Sabathia going to the NY Yankees, the market is weekend with starting pitching, and unless a deal can be made, the starting four looks like this. Johan Santana, Mike Pelfrey, John Maine, and Jonathan Neise vying for the fourth or fifth spot.
The new stadium poses a fresh start for the NY Mets, but what kind of team is going to lead the charge? The NY Mets need to find a ball player that is going to lead with his head and mouth, maybe not the best player but rather a player to gel all this super stardom into a playoff caliber team. If not, then the fans will feel right at home in their new quaint ballpark sitting on eggshells feeling like good old Shea.